O20 - Human rhinovirus replication-dependent induction of micro-RNAs in human bronchial epithelial cells
نویسندگان
چکیده
Background Micro-RNAs (miRNAs) are a class of small non-coding RNA molecules that function though post transcriptional regulation of gene expression by a process termed RNA interference (RNAi). RNAi–mediated targeting of viral RNAs is recognized as an antiviral defense mechanism. The epigenetic effect of miRNAs can either be direct, by interfering with virus genome, or indirect, through downregulation of type I IFN genes. The aim of this study is to identify HRV-A1B specific miRNAs in human broncheal cell line.
منابع مشابه
Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells.
Respiratory viral infections are responsible for 85% of asthma exacerbations, which in turn lead to increased morbidity and mortality, causing a high societal and economic burden [1, 2]. Asthma patients have been found to be more susceptible to viral infections compared with non-asthmatic individuals [3]. It has been postulated that a reduced induction of apoptosis in virally infected airway ep...
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